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KMID : 0605620080150010014
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Journal of Korean Society of Biological Psychiatry
2008 Volume.15 No. 1 p.14 ~ p.22
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Effects of Genetic and Environmental Factors on the Depression in Early Adulthood
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Kim Sie-Kyeong
Kim Heon
Eom Sang-Yong
Son Jung-Woo
Lee Sang-Ick
Shin Chul-Jin
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Abstract
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Objectives: The authors purposed to present data for explaining gene-environmental interaction causing depressive disorder by examining the effects of genetic factors related to the serotonin system and environmental factors such as stressful life events in early adulthood.
Methods: The subjects were 150 young adults(mean age 25.0+/-0.54), a part of 534 freshmen who had completed the previous study of genotyping of TPH1 gene. We assessed characteristics of life events, depression and anxiety scale and checked if they had a depressive disorder with DSM-IV SCID interview. Along with TPH1 A218C genotype confirmed in previous study, TPH2 -1463G/A and 5HTR2A -1438A/G genes were genotyped using the SNaPshotTM method.
Results: In comparison with the group without C allele of TPH1 gene, the number of life events had a significant effect on the probability of depressive disorder in the group with C allele. Other alleles or genotypes did not have a significant effect on the causality of life events and depressive disorder.
Conclusion: The results of this study suggest that TPH1 C allele is a significant predictor of onset of depressive disorder following environmental stress. It means that the TPH1 gene may affect the gene-environmental interaction of depressive disorder.
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KEYWORD
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Depressive disorder, Tryptophan hydroxylase, Serotonin receptor, Life stress, Gene-environment interaction
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